Things That Are Not Likely To Impact Bone Remodeling?

Bone remodeling is a lifelong process that replaces old and damaged bone with new bone through a sequence of cellular events occurring on the same surface without any change in bone shape. It is carried out through the work of osteoclasts, bone cells that resorb bone and dissolve its minerals, and osteoblasts, which are responsible for repairing old damaged bone due to daily physical load and preventing aging effects. The function of bone remodeling is to adjust the architecture to meet the changing needs of the body and repair microdamage in the bone matrix, which prevents impairment in the bone.

There are four stages in the repair of a broken bone: 1) the formation of hematoma at the break, 2) the formation of a fibrocartilaginous callus, and 3) the formation of a fracture. The purpose of bone remodeling is to regulate calcium homeostasis, repair micro-damage to bones from everyday stress, and shape the skeleton during growth.

Unlikely to affect bone remodeling are changes in parathyroid hormone, low blood Ca2+ concentration, glucagon, mechanical stress, age, bone type, drug therapy, and pre-existing bone disease. In adulthood, the rate of bone remodeling is highly variable and is influenced by age, genetics, physical activity, nutrition, and other modifiable factors such as low blood Ca2+ concentration, parathyroid hormone, glucagon, and mechanical stress. Acidosis and hypoxia generally increase bone resorption and inhibit bone formation, as hypoxia may cause acidosis through increased blood pressure.

What are the factors affecting bone health?

Research indicates that a balanced diet is crucial for bone health throughout life, with a focus on calcium and vitamin D. The Institute of Medicine recommends a steady increase in calcium intake as children age, starting with 210 mg per day in infants and rising to 1, 300 mg per day in those aged 9-18. Calcium intake drops to 1, 000 mg per day in those aged 19-50, and then increases to 1, 200 mg per day for those over age 50. The same age-dependent recommendations apply to pregnant or nursing women. Vitamin D intake is recommended at 200 IU per day for those under 50, 400 IU for those 50-70, and 600 IU for those over 70.

How does calcium affect bone remodeling?

Parathyroid hormone (PTH) plays a crucial role in bone remodeling, with high levels activating osteoclasts and causing excessive bone breakdown. Calcium levels in the blood trigger PTH release, with hypocalcemia causing high levels. Osteoporosis, a condition affecting 25% of women over 65 and 5% of men, is caused by larger holes in living tissue with a honeycomb-like appearance. Risk factors for osteoporosis include preventable and unavoidable factors. Bones affected by osteoporosis have larger holes and are more fragile.

Which of the following factors influence bone remodeling?

Bone remodeling is a process that involves the resorption of bone by osteoclasts and replacement by osteoblasts. It is crucial for maintaining calcium homeostasis, repairing damage from stress, and shaping the skeleton during growth. Bone growth factors, such as insulin-like growth factors I and II, transforming growth factor beta, fibroblast growth factor, platelet-derived growth factor, and bone morphogenetic proteins, influence the process. Bone volume is determined by the rates of bone formation and resorption.

Chemical factors control the action of osteoblasts and osteoclasts, either promoting or inhibiting the activity of bone remodeling cells. Postmenopausal osteoporosis is a result of imbalances in the relationship between bone resorption and replacement.

What are the 3 main things that affect bone remodeling?

Calcium-regulating hormones are crucial for producing healthy bones. Parathyroid hormone (PTH) maintains calcium levels and stimulates bone resorption and formation. Calcium-derived hormone calcitriol stimulates the intestines to absorb calcium and phosphorus, directly affecting bone. PTH also inhibits bone breakdown and may protect against excessively high calcium levels in the blood. PTH is produced by four small glands adjacent to the thyroid gland, which control calcium levels in the blood.

When calcium concentration decreases, PTH secretion increases. PTH conserves calcium and stimulates calcitriol production, increasing intestinal absorption of calcium. It also increases calcium movement from bone to blood. Hyperparathyroidism, caused by a small tumor of the parathyroid glands, can lead to bone loss. PTH stimulates bone formation and resorption, and when injected intermittently, bones become stronger. A new treatment for osteoporosis is based on PTH.

A second hormone related to PTH, parathyroid hormone-related protein (PTHrP), regulates cartilage and bone development in fetuses but can be over-produced by individuals with certain types of cancer. PTHrP causes excessive bone breakdown and abnormally high blood calcium levels, known as hypercalcemia of malignancy.

Which of the following affects bone remodeling?

The remodeling process of osteoclasts is influenced by various factors, including parathyroid hormone (PTH) and thyroxine, while it is decreased by estrogen, testosterone, vitamin D, calcium, high phosphorus levels, and other substances. The exact details of the remodeling process remain unclear, but it is believed that these factors contribute to the resorption of bone. The use of cookies is also a part of this process.

Which of the following would not influence bone as it remodels?

Glucagon elevates blood glucose levels by stimulating the breakdown of glycogen in the liver, yet it has no effect on bone remodeling.

Which of the following is unlikely to affect bone remodeling: low blood Ca2+ concentration, mechanical stress, glucagon, parathyroid hormone?

Glucagon is less likely to impact bone remodeling than other factors, including parathyroid hormone, low blood calcium, and mechanical stress. These factors are significantly influenced by calcium homeostasis and hormone actions on osteoblasts and osteoclasts.

What factors affect bone remodeling in Quizlet?

A number of factors have been identified as influencing bone growth and remodeling, including exercise, nutrition, vitamins C, A, K, B12, hormone effects, and calcitriol. The effects of exercise on bone are influenced by stress, while the effects of nutrition are characterized by the “use it or lose it” principle.

Which of the following is not related to bone remodeling responses?

Hematopoiesis, the formation of new blood cells, is not a component of the bone remodeling process, which encompasses the removal of old bone, the formation of new bone, and the maintenance of calcium homeostasis.

What are the 3 controls for bone remodeling?

The skeleton is a dynamic structure that undergoes continuous remodeling throughout its lifetime, responding to various factors such as hormones, cytokines, chemokines, and biomechanical stimuli. This process is vital for maintaining normal bone mass and strength and maintaining mineral homeostasis. Bone remodeling is regulated by a crosstalk between bone cells, with osteoclasts controlling resorption and osteoblasts promoting bone formation. Osteocytes, previously considered metabolically inactive cells, have recently gained interest as key regulatory components of the bone and one of the most important endocrine cells of the body.

The central nervous system (CNS) plays a vital role in bone turnover, with its neurotransmitters, neuropeptides, growth factors, and hormones playing vital roles. Extra-skeletal regulators, such as cerebral and hypothetically intestinal serotonin, also play a pivotal role in controlling new bone formation.

Bones are increasingly referred to as the central hormonal organs of the human body, regulating metabolism and affecting the function of other organs and tissues. Many pathologies of the skeleton may lead to systemic disorders, making further identification of other molecular mechanisms related to bone remodeling and metabolism essential for better understanding and defining novel strategies for treating skeletal and systemic diseases.

What are the factors affecting bone growth and Remodelling?

Bone growth is influenced by genetics, race, gender, and nutrition, and is maintained through bone remodeling throughout life. ScienceDirect uses cookies and cookies are used by the site. Copyright © 2024 Elsevier B. V., its licensors, and contributors. All rights reserved, including text and data mining, AI training, and similar technologies. Open access content follows Creative Commons licensing terms.